Cowboys vs 49ers Prediction: Odds, Picks & Betting Preview Week 5 – October 8, 2023

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On Sunday, October 8, 2023, the San Francisco 49ers (4-0) host the Dallas Cowboys (3-1) at Levi’s Stadium and will aim to continue a four-game winning streak.

49ers vs. Cowboys Odds

Point Spread

The spread for this matchup is set at 3.5 points, with oddsmakers listing the 49ers as the favorites.

Moneyline

As for the moneyline, the 49ers have -180 odds to pick up the win, while the Cowboys are listed at +150 to claim victory.

Over/Under

Finally, the total for the game is set at 45 points.

Game Info

How to Watch 49ers vs. Cowboys Live?

  • Game Day: Sunday, October 8, 2023
  • Game Time: 8:20 PM ET
  • TV Channel: NBC
  • Location: Santa Clara, California
  • Stadium: Levi’s Stadium

Betting Preview

49ers

The 49ers have been a difficult matchup for opposing teams, as they rank top-five in both total offense (second-best with 398 yards per game) and total defense (fifth-best with 284.3 yards allowed per game) this year. The 49ers have been a tough opponent for opposing teams, as they rank top-five in both scoring offense (third-best with 31.3 points per game) and scoring defense (third-best with 14.5 points allowed per game) this season.

The 49ers are compiling 245 passing yards per game on offense (ninth in the NFL), and they rank 17th defensively with 218.3 passing yards allowed per game. The 49ers have been a tough matchup for opposing teams in the running game, as they rank top-five in both rushing offense (third-best with 153 rushing yards per game) and rushing defense (third-best with 66 rushing yards allowed per game) this season.

The 49ers rank seventh in third-down efficiency (46.5%) on offense and 19th in third-down conversion rate allowed (41.1%) on defense this season. The 49ers have been thriving on both sides of the ball in terms of yards per play, ranking second-best in yards per play on offense (6.3) and third-best in yards per play allowed on defense (4.5). The 49ers have forced five total turnovers (12th in NFL) this season and have turned it over one time (first in NFL) for a turnover margin of +4, sixth-ranked in the NFL.

Cowboys

The Cowboys rank 11th in the NFL with 360 total yards per contest, but they’ve been lifted up by their defense, which ranks second-best by allowing just 259.8 total yards per game. The Cowboys have been top-five on both sides of the ball this season, as they rank fourth-best in points per game (31) and best in points surrendered per game (10.3).

The Cowboys have been thriving on pass defense, surrendering only 148 passing yards per contest (second-best). On offense, they rank 15th in the NFL by posting 218.8 passing yards per game. The Cowboys are compiling 141.3 rushing yards per contest on offense this season (seventh-ranked). Meanwhile, they are surrendering 111.8 rushing yards per game (17th-ranked) on defense.

Things have been positive for the Cowboys on both offense and defense on third down, as they are putting up a 51.6% third-down conversion rate (best) and surrendering a 30.6% third-down rate (fourth-best). In terms of yards per play, the Cowboys’ defense has been paving the way for the team, as they rank fifth-best in the NFL with 4.7 yards ceded per play. In terms of offense, they are generating 5.1 yards per play, which ranks 16th. Regarding turnover margin, the Cowboys are the best in the NFL this season. Their margin comes in at +9, as they’ve forced 10 turnovers and committed one.

49ers vs. Cowboys Injury Report

49ers

Player Pos. Injury Status
Elijah Mitchell RB Knee Out
Randy Gregory OLB Gameday inactive Out
Brandon Allen QB Gameday inactive Out
Brayden Willis TE Gameday inactive Out
Jalen Graham LB Gameday inactive Out

Cowboys

Player Pos. Injury Status
Trey Lance QB Gameday inactive Out
Peyton Hendershot TE Ankle Out
Damone Clark LB Shoulder Probable
Eric Scott Jr. CB Gameday inactive Out
Jalen Brooks WR Gameday inactive Out
Viliami Fehoko DE Gameday inactive Out

49ers vs. Cowboys Betting Analysis

49ers Betting Insights

The 49ers have registered a 3-1-0 record against the spread this season. The 49ers are 2-1 ATS when playing as at least 3.5-point favorites.

49ers games have gone over the total twice this season.

Cowboys Betting Insights

The Cowboys have put together a record of 3-1-0 against the spread this season.

This year, Cowboys games have hit the over twice. This is the first time the Cowboys will play as underdogs this season.

The Cowboys have not entered a game this season with longer moneyline odds than +150.

49ers vs. Cowboys Against The Spread & Betting Records

49ers

Overall Home Away
Point Total AVG 43.5 43.8 43.3
Implied Team Total AVG 26.3 28.5 24
ATS Record 3-1-0 2-0-0 1-1-0
Over/Under Record 2-2-0 1-1-0 1-1-0
Moneyline Favorite Record 4-0 2-0 2-0
Moneyline Underdog Record 0-0 0-0 0-0

Cowboys

Overall Home Away
Point Total AVG 42.4 40.8 44
Implied Team Total AVG 25.3 24.5 26
ATS Record 3-1-0 2-0-0 1-1-0
Over/Under Record 2-2-0 1-1-0 1-1-0
Moneyline Favorite Record 3-1 2-0 1-1
Moneyline Underdog Record 0-0 0-0 0-0

Players to Watch

49ers

  • Christian McCaffrey’s rushing stat line this season includes 459 yards (first in the NFL) and six TDs. He is averaging 114.8 yards per game and 5.7 per attempt (sixth in the NFL).
  • He has hauled in 18 passes (on 21 targets) for 141 receiving yards with one touchdown. He’s averaging 35.3 receving yards and 4.5 catches per game.
  • Brock Purdy has 1,019 passing yards (10th in the NFL), five touchdowns and zero interceptions this year. He has completed 72.3% of his passes, averaging 254.8 yards per game and 9.1 per attempt.
  • He has added 24 rushing yards (6 per game) and two touchdowns on the ground.
  • In three games played, Brandon Aiyuk is averaging 106.7 yards and 5.7 receptions per game on the way to 320 receiving yards and 17 catches. He’s been targeted 20 times, and has two receiving touchdowns.
  • Deebo Samuel has put up 247 receiving yards and one touchdown with 17 catches on 28 targets. He is averaging 4.3 receptions and 61.8 yards per game.
  • Over on defense, Fred Warner has 33 tackles, two TFL, one sack, and two passes defended in 2023.
  • Deommodore Lenoir has 30 tackles and one interception this season. He’s third on the 49ers in tackles.
  • Dre Greenlaw has put up 32 tackles and one TFL this year.
  • This season, Javon Hargrave has 11 tackles, three TFL, and three sacks.

Cowboys

  • Dak Prescott is averaging 6.7 passing yards per attempt (20th in the NFL) and 227 yards per game this year, completing 71.3% of his passes on the way to 908 total yards, four touchdowns and one interception through four games.
  • Prescott has also rushed for 43 yards (fourth on the Cowboys).
  • Tony Pollard has scored two rushing touchdowns, while totaling 311 rushing yards (4.3 per carry and 77.8 per game).
  • Pollard has also collected 61 receiving yards (15.3 per game) on 15 catches (3.8 per game). He’s been targeted 17 times and is still trying for his first receiving touchdown.
  • CeeDee Lamb has registered 309 receiving yards and one touchdown on 23 receptions, while being targeted 30 times on the season.
  • Jake Ferguson has 147 receiving yards and one touchdown from 17 receptions after receiving 25 targets.
  • Micah Parsons has 14 tackles, six TFL, four sacks, and one pass defended in 2023.
  • Daron Bland has 14 tackles, one TFL, and three interceptions. He is fifth on the Cowboys in tackles.
  • Over the 2023 season, Leighton Vander Esch has 20 tackles through four games.
  • Osa Odighizuwa’s stats include 11 tackles, four TFL, and three sacks in four games

49ers vs. Cowboys Predictions and Pick

Our prediction to win this game is the 49ers, and we expect that 49ers will cover the spread (49ers -3.5). Finally, we see the scoring in this one going under the posted total of 45 points.

How to Bet on 49ers vs. Cowboys

You can bet this 49ers vs. Cowboys pick at every legal online sportsbook

You can check our live NFL lines for the latest NFL odds, including money lines, spreads, and over/under totals.

Tip: If you want to check out how much you could win on a $10 bet if you parlayed today’s 49ers vs. Cowboys picks, don’t forget to check out our free parlay calculator.

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WRITTEN BY

Matt Rooney

Matt comes from Chicago and has lived in the area his whole life. Graduated from and played football at Illinois Wesleyan University in Bloomington, IL while also serving as the director of student sports broadcasting. He writes for Betsperts as well as appears on several shows across the network.

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